Four suspects in the assassination of Haiti’s President Jovenel Moise have been gunned down by security forces in a shootout and two others have been detained, police said.

Officers are still in combat with some remaining suspects in Haiti capital Port-au-Prince, a report cited officials.

“They will be killed or captured,” police chief Leon Charles said.

Moise, 53, was fatally shot and his wife was injured when attackers stormed their home early on Wednesday.

The unidentified gunmen entered the private residence in Port-au-Prince at 1 am local time. Moise was killed, but First Lady Martine Moise survived and has been flown to Florida where she is under treatment.

She is reported to be in a stable but critical condition.

“Four mercenaries were killed (and) two were intercepted under our control,” Charles said in a televised statement late on Wednesday. “Three policemen who had been taken hostage have been recovered.”

“We blocked (the suspects) en route as they left the scene of the crime,” he added. “Since then, we have been battling with them.”

Speaking after the killing, interim Prime Minister Claude Joseph called for calm and declared a nationwide state of emergency.

The state of emergency, or “state of siege”, allows for the banning of gatherings and use of the military for police roles, along with other extensions of executive powers.

US President Joe Biden offered condolences to the people of Haiti for the “horrific assassination”. UK Prime Minister Boris Johnson, meanwhile, called it “an abhorrent act” and also appealed for calm.

Moise became president of Haiti in 2017, but in recent times faced widespread protests demanding his resignation.

Coups, political instability, widespread gang violence and natural disasters have plagued the country for decades and rendered it the poorest nation in the Americas.

Joseph said the attackers were “foreigners who spoke English and Spanish”. Haiti’s official languages are Creole and French.

Some reports spoke of men dressed in black who carried high-powered weapons who may have pretended to be part of a US drug enforcement operation, although no official details have been given.

Haiti’s ambassador to the US, Bocchit Edmond, said there was “no way” US drugs agents carried out the attack. He believed it was the work of “professional mercenaries”.