The victory, which helped England move to the top, was a sweet revenge for Gareth Southgate's men after losing their last two encounters against Belgium.
Cristiano Ronaldo opened the score by firing a freekick before the break, then added a second by curling home from the edge of the penalty area in the 73rd minute.
The victory also moved the 2006 world champions Italy to top spot in Group A1 with four points from two games, one point clear of the Dutch.
Kylian Mbappe, who is asymptomatic as reported by RMC Sports, has left the national team squad and begun his home quarantine.
Mbappe's goal in the 41st minute was his 14th goal for his country. The 21-year-old cut in from the left and found the gap between Sweden goalkeeper Robin Olsen and the post
Spain left it late and flabbergasted the hosts when Moreno flicked on a cross before Gaya poked home with a turn shot from very close range.
This is the second revised schedule of a UEFA competition released by the governing body after new dates for Champions League were released earlier.
