Barca will be at home to Celta Vigo on Saturday night after qualifying for the semifinal of the Champions League despite a 3-1 defeat to Borussia Dortmund on Tuesday night.
Betis has suffered a serious setback with the confirmation central defender Diego Llorente needs an operation and will miss the rest of the season.
FC Barcelona coach Hansi Flick is likely to have only two central defenders available for his side's rescheduled La Liga game at home to Osasuna on Thursday night.
After Real Madrid head coach Carlo Ancelotti issued a warning towards La Liga claiming his side will not take the pitch if they are made to play two games in a period of less than 72 hours, La Liga president Javier Tebas pointed out that Los Blancos will be playing in a period shorter than 72 hours in the coming weeks due to their own demands.
La Liga goes into its last round of matches before the first international break of 2025. Former champions Barcelona will be hoping to extend their lead by adding to their current tally of 57 points from 26 matches.
La Liga goes into the final international break of the year with Girona as the surprise leader of the classification, while FC Barcelona is struggling for form, and at the bottom, Almeria looked doomed to relegation.
Wednesday night features five matches in the 36th round of La Liga, headlined by a Madrid derby and three significant games where the fight against relegation is the key issue.
The Spanish La Liga has no time for a pause as this week sees the 36th round of matches, with plenty still to play for and three games on Tuesday night.
La Liga leaders FC Barcelona suffered a 2-1 defeat away to Rayo Vallecano after another lackluster display from Xavi Hernandez's team.
Marcos Andre joined Valencia's injury list this week, leaving the veteran Edinson Cavani as their only fit striker.
