Andreescu, 19, who clinched her second professional title at the Women's Tennis Association Premier 5 event in Toronto, needed just one hour and 55 minutes to reach her first Grand Slam quarterfinals.
On Sunday, Williams entered the US Open quarters for the 16th time in her career with a straight-set win over Petra Martic of Croatia at an electric Arthur Ashe Stadium.
In other second-round action on Wednesday, American Danielle Collins defeated Vera Lapko of Belarus 6-1, 3-6, 6-1.
Konta, who captured her first WTA title two years ago at Stanford, got on a roll and didn't take a chance in letting Williams get back in it.
Johanna Konta believes that the lack of a clear favourite for the Australian Open reflects the growing strength in depth…
In the first round, Svitolina, seeded No.3, defeated Spain's Carla Suarez Navarro 6-2, 6-4 in almost one-and-half hours
Twenty years after making her Wimbledon debut, five-time champion Williams is into her ninth final at the All England Club .
Konta has won three of their last five meetings, but Venus took the spoils the last time they clashed.
Williams' victory equalled her sister Serena's total of 86 main draw match victories at Wimbledon.
Meanwhile, Victoria Azarenka continued her comeback bid with an easy win over Elena Vesnina.
