Juventus forward Paulo Dybala is in doubt for Argentina's 2018 football World Cup qualifiers against Chile and Bolivia due to a leg injury.
The 23-year-old did not train with Argentina's squad in Buenos Aires on Tuesday as he struggles to recover from a thigh strain he suffered during Juventus 1-0 win over Sampdoria in the Serie A on Sunday, reports Xinhua news agency.
Reports in Argentine media said Dybala was likely to miss the clash with Chile at the Monumental Stadium but could still be available for the duel against Bolivia in La Paz next Tuesday.
His absence on Thursday could hand a starting berth to Manchester City striker Sergio Aguero, who had been expected to start the match on the bench.
Argentina will also be without Aguero's Manchester City teammate Pablo Zabaleta for the fixtures because of a thigh injury.
Argentina are currently fifth in the South American zone World Cup qualifying standings, eight points behind leaders Brazil.
The top four teams from South America will automatically qualify for the tournament in Russia while the fifth-ranked side will earn a playoff spot.